Patent - A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface. Tissue adhesives have been increasingly used to enhance traditional closure technologies such as sutures and staples, offering improved sealing capabilities and plugging of undesired leaks 1 . However, despite recent developments and increased clinical demand, currently available products still suffer from serious drawbacks. While synthetic adhesives have low biocompatibility, low adherence to wet surfaces and potential toxicity, the biological glues are costly, often show relatively poor mechanical and tissue-bonding properties, and are potentially immunogenic, as most of them are based on proteins. Thus, there is a genuine unmet need for non-toxic, strong, and economical tissue sealants to sustain internal surgical incision closure, as an adjunct to suturing or stapling. This need was the main motivation for the development of bio-mimicking adhesives, which received increasing attention in the last decade. Using the biomimetic approach, the inventors of the present invention hypothesized that the natural components of the “fucus glue” can be successfully replaced with commercially available analogue that provides similar functionally. In PCT/IL2006/000289, the inventors of the present invention indeed showed that the monomeric unit of phloroglucinol and several of its derivatives to interact with polysaccharide such as alginate to form an adhesive that was shown to adhere in various compositions to animal tissues as well as to other surfaces. Moreover, the method of applying the adhesive materials seems to play an important role in the ability to utilize the adhesive composition of matter as an effective sealant. The inventors of the present invention developed methods of applying the adhesive material that allow on-site curing of the adhesive and usage of bandages that form with the adhesive material an affective sealant especially for medical use.
Source : APN 01-20-11 20110015759/US-A1 NDN- 041-1134-8749-4 INVENTOR- Bianco-Peled, Havazelet Haifa, IL INVENTOR- Kimhi, Ohad Kiryat Yam, IL APPLICANT- TECHNION-RESEARCH $#amp DEVELOPMENT FOUNDATION LTD HAIFA, IL PATENT APPLICATION NUMBER- 741495/12 DATE FILED- 2008-11-05 PUBLICATION NUMBER- 20110015759/US-A1 PUBLICATION DATE- 2011-01-20 MAILING ADDRESS- BROWDY AND NEIMARK, P.L.L.C;624 NINTH STREET, NW; SUITE 300; WASHINGTON; DC; 20001-5303; US FIRM- BROWDY AND NEIMARK, P.L.L.C;624 NINTH STREET, NW US PATENT CLASS- 623023720O; X106162100; X427384000 INTERNATIONAL PATENT CLASS- A61F00200; C09J10500
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